C1Q ASSAY RESULTS IN COMPLEMENT-DEPENDENT CYTOTOXICITY CROSSMATCH NEGATIVE RENAL TRANSPLANT CANDIDATES WITH DONOR-SPECIFIC ANTIBODIES: HIGH SPECIFICITY BUT LOW SENSITIVITY WHEN PREDICTING FLOW CROSSMATCH
CH 28 : José M. Arreola-Guerra, Luis E. Morales-Buenrostro, Natalia Castelán, Adrián de Santiago, Adriana Arvizu, Norma Gonzalez-Tableros, Mayra López, Mario Vilatobá, Julio Granados, and Josefina Alberú
In complement dependent cytotoxicity crossmatch negative renal transplant candidates with human leukocyte antigen donor-specific antibodies (DSA), both the presence of DSA C1q+ and the dominant DSA fluorescence were significantly associated with a positive flow cytometry crossmatch (FXM+). The C1q+ assay was highly specific, but had low sensitivity when predicting FXM+, so the clinical significance of a FXM+ in the absence
of DSA C1q+ remains to be clarified in future studies.
C1q Assay Results in Complement-Dependent Cytotoxicity Crossmatch Negative Renal Transplant Candidates with Donor-Specific Antibodies High Specificity But Low Sensitivity When Predicting Flow Crossmatch
- Product Code: CT15_Ch28
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