ALLOANTIBODIES IN ORGAN TRANSPLANT: A REVIEW OF DATA PUBLISHED IN 2015

CH 13 : Curtis Maehara and Matthew J. Everly

Abstract

In recent years, there have been multiple studies published on longitudinal and retrospective analysis of anti-human leukocyte antigen (anti-
HLA) antibodies. The focus of these reports was to determine specific characteristics of the impact of donor specific anti-HLA antibodies (DSA) in
organ transplantation. There has been a growing concern about DSA in a multitude of organ transplants. Research efforts are attempting to
gain a better understanding of DSA and possible treatment implications for patients with DSA. In 2015, many studies confirm and expand upon both the understanding of the humoral theory and the clinical applications of DSA in transplantation. This review highlights some of these publications and their contributions to the humoral theory of transplantation.