1.7 Year Follow-up After Bortezomib Therapy for Refractory Antibody Mediated Rejection.

Shapiro R, Lunz J, Zeevi A, Basu A, Mapara M, Randhawa P, Tan HP, Sharma V, Humar A.

Clinical Transplants 2010, Chapter 39

Abstract

In summary, 1.7 years after transplantation, bortezomib rescue has been durably effective in salvaging our patient with refractory antibody mediated rejection. The only price has been persistently high levels of BK viruria. The presence of ongoing and even recurrent donor specific antibody has made it difficult to reduce immunosuppression further, and the concern that the high levels of BK viruria will eventually progress to viremia and nephropathy necessitates continued therapy with very low dose cidofovir and leflunomide. The absence of C1q binding DSA with stable renal function may provide some reserved optimism that the DSA that is detectable by convention Luminex assay may have reduced pathological implications. However, more data and prolonged follow-up are needed to determine whether or not non-complement binding DSA has an adverse pathological role.