Successful Desensitization in a Crossmatch Positive Living-related Kidney Transplant Recipient Using a Bortezomib-based Protocol.

Zhu L, Lin Z, Xiang Y, Liu S, Chen G.

Clinical Transplants 2009, Chapter 30

Abstract

This is a case of one patient who was treated with a bortezomib-based desensitization regimen to treat sensitization obtained though a previous transplant lost to chronic rejection. This regimen successfully convert a positive crossmatch to negative, prevented both hyperacute and acute rejections out to 3-months post transplant, and was without any noticeable side effects. This account demonstrates that desensitization by bortezomib combined with plasmapheresis and low-dose IVIG is a possible way to transplant a highly sensitized patient.