HLA and MICA Antibodies: Further Evidence of Their Impact on Graft Loss Two Years After Their Detection.

Morales-Buenrostro LE, Rodríguez-Romo R, de Leo C, López M, Pérez-Garrido J, Uribe-Uribe N, Alberú J.

Clinical Transplants 006, Chapter 15

Abstract

1. At the median post-transplant follow-up (to Ab evaluation) of 51.4 months, the prevalence of anti-HLA and anti-MICA Abs was 21.9% and 19%, respectively. 2. Overall, of the 196 patients included, 124 (63.3%) were negative to all tested Abs, and 72 (36.7%) were positive for: HLA Abs alone = 34; MICA Abs alone = 29; and HLA  MICAAbs = 9. 3. Two years after Ab evaluation, graft survival was significantly lower for patients with HLA  MICA Abs (p = 0.046). 4. The proportion of patients without CNI drugs at the time of Ab evaluation was greater in patients with one Ab and even greater in those with two Abs (HLA  MICA) when compared to patients with a negative Ab determination (p = 0.037).