Personalized Physiological Models
The organs-on-a-chip platforms seek to recapitulate human organ functions at microscale by integrating microfluidic networks with three-dimensional tissue models, which are expected to provide robust and accurate predictions of drug/toxin effects in human bodies. Since induced pluripotent stem cells can be obtained from patient-derived cells such as skin or blood, it may enable personalized treatment or disease models with exactly the same genomic background as the patient. With recent advances in genome editing technology, cells with genetically desirable phenotypes, such as the expression of desired biomarkers, could be easily generated. Based on these high-end scientific endeavors, the Terasaki Institute is developing the most state-of-the-art organs-on-a-chip platforms with integrated bioreactors containing human tissue constructs and online sensors for real-time monitoring of both physical and biochemical parameters of the organoids. We are developing personalized physiological models with precisely designed genetic properties that provide a versatile platform to generate accurate medical therapies. Our efforts enable us to observe the basic function of cells and the input and output relationship allowing us to minimize the use of animal testing.