News

 Dr. Ali Khademhosseini awarded IAAM Fellowship

July 28, 2020

 

Dr. Ali Khademhosseini of the Terasaki Institute for Biomedical Innovation (TIBI) has been awarded a fellowship from the International Association of Advanced Materials (IAAM), for him and his team’s groundbreaking work in precision medicine and the facilitation of its real-world applications in the public health field. He has most notably led the effort in tissue engineering, developing smart devices and materials for diagnostics and therapeutic drug delivery, and perfecting 3D-printed architectures of personalized surgical implants for patients in need. He is distinguished among the brightest and most impactful scientists for his commitment to assure and distribute his knowledge and methods of personalized health to as many people in need as possible.

New Book Applies the Latest Engineering Technologies to Medicine and Biological Research

July 20, 2020

 

From the burgeoning field of biomedical engineering and the ever-present need to provide solutions for medical problems, a new resource has been created that joins engineering technologies with biological research and medicine.  A comprehensive new book entitled “Interfacing Bioelectronics and Biomedical Sensing, and co-edited by Ali Khademhosseini of the Terasaki Institute for Biomedical Engineering, Hung Cao of UC Irvine, Todd Coleman of UC San Diego and Tzung Hsiai from UCLA, has been recently published by Springer Nature.   

Cardiac Scar Tissue: A Factor Which Regulates Its Size

July 13, 2020

 

Component of tissue is shown to limit the amount of scarring after heart attack. 

 

(LOS ANGELES) –  When a person has a heart attack, the person’s coronary artery is blocked, cutting off the flow of blood and oxygen to that portion of the person’s heart.  The surrounding heart muscle may be damaged to an extent depending on the size of the blocked area and the time between the attack and treatment. Upon recovery, the heart muscle starts to heal, and like a skin wound, it may form a scar.  The size and location of the scar can vary greatly, and there is a possibility to develop additional complications or even death. 

Regenerating the Body From Within Using Biomaterials

July 6, 2020

 

Materials to enhance the body’s own regenerative capabilities 

 

(LOS ANGELES) – Successful tissue regeneration can have major benefits in healing injuries or replacing portions of diseased or damaged tissue in bone, skin, the nervous system and in organs such as the muscle, kidney, liver, lung, and heart.  But the effectiveness of the body’s own system for repairing such damage can vary greatly, depending on the kind of tissue involved and its location.  Tissue engineers have been working to address these limitations by creating substances called biomaterials, which can be used in various ways to boost the body’s ability to heal.  In a recent publication in Nature Reviews MaterialsAli Khademhosseini, Ph.D., Director and CEO of the Terasaki Institute, and colleagues discuss the use of biomaterials for tissue regeneration. 

The COVID-19 Kidney / Transplant Listening & Resource Center

July 2, 2020

 

New call center to answer questions, educate, and support the dialysis and transplant community. 

(LOS ANGELES) –

The Transplant Research and Education Center (TREC), housed at the Terasaki Research Institute for Biomedical Innovation (TIBI), launched the COVID-19 Kidney / Transplant Listening & Resource Center (KTLRC) on June 17, 2020. The KTLRC is a vital new service created in direct response to the unique and unmet needs of the dialysis and organ transplant community during the COVID-19 Pandemic. The KTLRC is a toll-free call center that allows patients, their loved ones, and caregivers to connect with our experienced education team to share their questions, concerns, and receive answers, education, and referrals for additional resources.  

The KTLRC can be reached at: 

1-800-830-0484 

This email address is being protected from spambots. You need JavaScript enabled to view it. 

Directly Printing 3D Tissues Within the Body

June 15, 2020

 

Researchers take a step closer to 3D printing living tissues in patients

(LOS ANGELES) – In the TV series Westworld, human body parts are built on robotic frames using 3D printers.  While still far from this scenario, 3D printers are being increasingly used in medicine.  For example, 3D printing can be used to produce parts of the body such as orthopedic joints and prosthetics, as well as portions of bone, skin and blood vessels.  However, the majority of these tissues are created in an apparatus outside of the body and surgically implanted.  Such a procedure may involve making large surgical incisions, posing the added risk of infection and increased recovery time for the patient.  And since there is a time lapse between when the tissue is created and when it is implanted in the patient, further complications may occur.  To prevent these complications, a team of scientists have developed a technology to print tissues directly in the body.

Microneedling therapeutic stem cells into damaged tissues

June 9, 2020

 

Small and minimally invasive “Detachable Microneedle Depots” effectively deliver stem cells for localized MSC therapy of skin disorders

 

(LOS ANGELES) — Mesenchymal stem cells (MSCs) are multipotent in that they naturally replenish the cell types that build our bone, cartilage and adipose tissues. However, their much broader regenerative potential, based on their capacity to migrate and engraft in injured tissues and secrete factors that enhance the formation of new blood vessels, suppress inflammation and cell death, and promote healing, makes them exquisite candidates for cell-based therapies for diseases as varied as cardiovascular, liver, bone and cartilage diseases, lung and spinal cord injuries, autoimmune diseases and even cancer and skin lesions.

 

Extraction of Skin Interstitial Fluid Using Microneedle Patches

May 27, 2020

Researchers at the Terasaki Institute enhance tool for extraction of samples used in monitoring patient health

 

(LOS ANGELES) – The interstitial fluid is a major component of the liquid environment in the body and fills the spaces between the body’s cells.  In contrast, blood circulates only within the circulatory vessels of the body and is composed of blood cells and the liquid part of the blood, plasma.  Both fluids contain special components called biomarkers, which are valuable indicators of bodily health.  These biomarkers include various types of molecules such as proteins, hormones or DNA, and can also include drugs and metabolites.

When monitoring patient health, the standard source for the measurement of biomarkers is blood.  Samples are drawn by venous puncture, most often from the forearm or from the veins in the hand.  Occasionally there are problems in drawing blood when the veins are subject to collapse, or when they are very small or difficult to locate.  Still other problems may occur when the veins “roll” or move from side to side.  And as in any procedure that involves a wound to the skin, there is always the risk of infection that is introduced.  The problems are compounded when patients are required to submit multiple samples over time.

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