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Microneedles For Therapeutic Gene Delivery

October 7, 2020

Researchers develop a minimally invasive biodegradable microneedle patch as a novel delivery mode for gene therapy applications

(LOS ANGELES) - There is great potential in gene therapy for treating certain types of cancer and genetic defects, immunological diseases, wounds and infections. The therapies work by delivering genes into the patients' cells, which then produce therapeutic proteins to treat the affliction.

When determining the method of delivery for these genes, there are advantages to choosing a local, rather than systemic delivery of the genetic material. With systemic delivery, there is the possibility of unwanted tissue accumulation or of the genetic material becoming unstable. It is also advantageous to target the skin as a site for local delivery, as it is easily accessible and contains fluid and lymph vessels, as well as immune cells upon which the genetic material can act to initiate treatment.

Terasaki Institute Welcomes New Director

Septemer 23, 2020

(LOS ANGELES) - The Terasaki Institute for Biomedical Innovation welcomes its Director and CEO, Ali Khademhosseini, PhD, who joins the institute with extensive research and leadership experience in the field of biomedical technology.  He is formerly a Professor of Bioengineering at the University of California Los Angeles (UCLA) and a Professor at Harvard Medical School/MITHe is joining the institute from Amazon, Inc, where he recently completed his sabbatical.  He is recognized as a world-renowned leader in combining micro- and nano-engineering approaches with advanced biomaterials for regenerative medicine applications and has authored over 600 peer-reviewed journal papers.  In addition, Dr. Khademhosseini is a co-founder and Scientific Board Member of Obsidio, Incorporated, a biomaterials technology startup company. 

The Transplant Research and Education Center (TREC) Offers a Tailored Education System to Benefit Kidney Transplant Patients

September 16, 2020

Researchers find their computer-tailored education system, Your Path to Transplant” increases knowledge and readiness to pursue kidney transplant  

(LOS ANGELES) – Patients with chronic kidney disease and end-stage renal disease have to go to a dialysis center for hours at a time, several times a week for the rest of their lives. Patients on dialysis have strict dietary restrictions, and have difficulty maintaining a job or school with all of the hours that are spent at the dialysis center each week. Often, dialysis is the main treatment doctors tell patients about, so patients go along with it. However, a living donor kidney transplant is the most effective treatment for end-stage renal disease.  Past research has shown that doctors typically spend about a half an hour giving patients  large quantities of information all at once about transplantation, which causes patients to become overwhelmed with the decision.  

Oxygen-Releasing Bioink for 3D Bioprinting

September 9, 2020

Newly developed bioink enhances the ability of implanted cells to grow and regenerate new tissue 

(LOS ANGELES) – Engineering new tissues can be used to alleviate shortages of organs in transplantation, as well as to develop physiological models for drug discovery applications. One of the emerging approaches to building tissues is through 3D Printing, where cells and materials can be combined to make inks that can generate tissue structures. One of the limitations for making new tissues is that they require oxygen to survive. This oxygen is delivered through blood vessels, which take a few days to develop in a transplanted tissue.  

Key Priorities for Transplant and Living Donor Advocacy during COVID-19 and Beyond

September 4, 2020

Researchers describe ways to achieve optimal patient advocacy for kidney recipients and donors during the COVID-19 pandemic and beyond 

(LOS ANGELES) – In a newly published paper, the authors first paint the vision of what optimal patient advocacy can do to overcome the challenges described by kidney transplant patients and donors, and then describe how to make that vision a reality, especially during the COVID-19 pandemic. Dr. Amy Waterman, Deputy Director at the Terasaki Institute for Biomedical Innovation and leader of the Transplant Research and Education Center (TREC), assembled a panel of patients to learn their priorities for their care during this unprecedented time. 

Ali Khademhosseini Elected As Senior Member of the National Academy of Inventors

August 18, 2020

(LOS ANGELES) – The National Academy of Inventors (NAI) has elected Ali Khademhosseini, Ph.D., of the Terasaki Institute for Biomedical Innovation, to the rank of NAI Senior Member.  The NAI Senior Member Advisory Committee has chosen to honor him for his achievements and contributions to the innovation ecosystem at the NAI Member Institution, and he will be recognized formally at their tenth anniversary annual meeting on June 7-9, 2021. 

Terasaki Institute Welcomes Chief Innovation Officer

August 18, 2020

(LOS ANGELES) – The Terasaki Institute for Biomedical Innovation (TIBI) is pleased to welcome Maurizio Vecchione as its Chief Innovation Officer.  Maurizio has spent the last 30 years at the forefront of global and public health, focusing on innovation to improve the lives of the world’s most vulnerable people. From 2014 until 2020, he was the Executive Vice President for Global Good and Research at Intellectual Ventures (IV), where he oversaw collaboration with Bill Gates to invent and deploy technology to address some of humanity’s most daunting challenges.

Author Rankings in the Field of 3D Bioprinting

August 5, 2020

A recent study published in the Journal of Biomedical Semantics performed an analysis and ranking of the most prominent, influential and prolific authors in the rapidly expanding field of 3D bioprinting.  The findings revealed that Ali Khademhosseini, Ph.D., of the Terasaki Institute for Biomedical Innovation, ranked as the second-most prolific author in terms of productivity, citation impact, and collaborative networking. 

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