BEGIN:VCALENDAR VERSION:2.0 CALSCALE:GREGORIAN METHOD:REQUEST BEGIN:VEVENT UID:6606772136760 DTSTART:20220921T180000Z DTEND:20220921T190000Z DTSTAMP:20220921T180000Z ORGANIZER;CN=Terasaki Institute:mailto:events@terasaki.org CREATED:20240329T080905Z DESCRIPTION:Cellular and tissue engineering promises new therapeutic options for people suffering from a wide range of diseases. Differentiation of stem cells is a powerful renewable source of these functional replacement cells and tissues that can be grown in the laboratory. Diabetes is cause by the death or dysfunction of insulin-secreting islets\, which are a tissue type found in the pancreas that contain β cells and other endocrine cell types. We have recently developed approaches combining modulating the actin cytoskeleton and signal transduction pathways during differentiation to produce stem cell-derived islets (SC-islets) capable of undergoing glucose-stimulated insulin secretion\, their primary function. We have further expanded this approach to make SC-islets from patients with diabetes and used CRISPR-Cas9 to correct their diabetes-causing mutations. Upon transplantation into mice with severe pre-existing diabetes\, these SC-islets rapidly restore normoglycemia and can maintain this functional cure for a year. Our hope is that one day this technology can be used to replace unhealthy islets in patients for therapy and provide a better disease-in-a-dish model to discover new drugs to prevent\, stop\, or reverse diabetes progression. LAST-MODIFIED:20220921T180000Z LOCATION: SUMMARY:Terasaki Talks Presents: “Engineering of Multi-Cellular Insulin Secreting Tissues for Diabetes Cell Replacement Therapy”\, Presenter: Prof. Jeffrey R. Millman SEQUENCE:0 TRANSP:OPAQUE END:VEVENT END:VCALENDAR