BEGIN:VCALENDAR VERSION:2.0 CALSCALE:GREGORIAN METHOD:REQUEST BEGIN:VEVENT UID:6606cfea46556 DTSTART:20220824T180000Z DTEND:20220824T190000Z DTSTAMP:20220824T180000Z ORGANIZER;CN=Terasaki Institute:mailto:events@terasaki.org CREATED:20240329T142754Z DESCRIPTION:Abstract:Acetalated dextran (Ac-DEX) is an acid-labile polymer originally developed for vaccine formulations\, with the idea that vaccine elements could be encapsulated in the biopolymer to be phagocytosed by antigen presenting cells\, resulting in pH shift in the phagosome that results in triggered intracellular release. Since its original development\, Ac-DEX has also illustrated highly tunable release kinetics based on the cyclic and acyclic acetal coverage of the pendent dextran hydroxyl groups. This finely tunable degradation rate as well as the acid sensitivity has illustrated that microparticulate formulations can be used to optimize universal flu vaccine efficacy. Additionally\, these material properties can be used to formulate nanofibrous scaffolds that optimally deliver chemotherapeutics in glioblastoma resection cavities. LAST-MODIFIED:20220824T180000Z LOCATION: SUMMARY:Terasaki Talks Presents: “Acetalated Dextran: A Spoonful of Sugar Helps the Medicine (and Vaccines) go Down!”\, Presenter: Prof. Kristy Ainslie SEQUENCE:0 TRANSP:OPAQUE END:VEVENT END:VCALENDAR