Terasaki Talks Presents: "Cellular Hitchhiking for Targeting Cancer", Dr.Samir Mitragotri


John A Paulson School of Engineering & Applied Sciences, Wyss Institute, Harvard University, Cambridge, MA 02138

Nanoparticle-based drug delivery systems are widely explored to improve the biological outcome of chemo and immunotherapy. However, poor vascular circulation, limited targeting and the inability to negotiate many biological barriers are key hurdles in their clinical translation. Biology has provided many examples of successful “carriers” in the form of circulatory cells, which routinely overcome the hurdles faced by synthetic nanoparticle systems. Our laboratory has explored blood-cell inspired drug delivery systems that take advantage of the abilities of red blood cells and macrophages. We have explored “cellular hitchhiking” which involves combining synthetic particles with circulatory cells to drastically alter the in vivo fate of the synthetic particles. I will provide an overview of the principles and two examples of hitchhiking-based cancer chemo and immunotherapy. Samir Mitragotri is the Hiller Professor of Bioengineering and Wyss Professor of Biologically Inspired Engineering at Harvard University. His research has provided new insights into biological barriers of skin, blood-brain barrier, immune clearance and gastrointestinal tract, among others. His research has also led to new methods of transdermal, oral, and targeted drug delivery systems. He is an author of over 300 publications and is a Thomson Reuters Highly Cited Researcher. Prof Mitragotri is an inventor on over 180 patent/patent applications. He is an elected member of the National Academy of Engineering, National Academy of Medicine and National Academy of Inventors. He is a foreign member of Indian National Academy of Engineering. He is also an elected fellow of AAAS, CRS, BMES, AIMBE, and AAPS. He received BS in Chemical Engineering from the Institute of Chemical Technology, India and PhD in Chemical Engineering from the Massachusetts Institute of Technology. He is the Editor-in-Chief of AIChE’s and SBE’s journal Bioengineering and Translational Medicine.

Event Information

Event Date 10-21-2020 8:00 am
Event End Date 10-21-2020 9:00 am
Registration Start Date 09-27-2020
Cut off date 10-21-2020 8:00 am
We are no longer accepting registration for this event

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