TIBI Presents "Creating High Quality Schematics with Powerpoint", Presenter: Xingwu Zhou

“Bioengineered Oral Medicine to Treat Obesity and Diabetes”

Abstract:

Obesity is considered a strong factor in many chronic diseases, including heart disease, cancer, and diabetes. Along with genetics, consumption of excessive fat and cholesterol-rich food are the primary causes of obesity. However, despite of an alarming emergency there has been little progress made developing medications for controlling obesity, conveniently and effectively.

In this seminar, I will talk about various approaches of treating type 2 diabetes and obesity using oral formulations such as ionic liquid that prevents the fat from penetrating through the intestinal membrane. In our recent study we have observed that a regular oral dose of ionic liquid may result less body weight gain compared with the control/untreated rats. On the same line, we have developed an oral formulation to deliver DNA encoded-glucagon like peptide-1 to treat T2D, shows significant reduction of body weight and blood glucose level in rat model.