Joo-Young Ohe received her Ph.D from Kyunghee University, South Korea in 2012. During Ph.D. degree, she studied the effects of growth and differentiation factor 5 (GDF-5) for bone tissue regeneration and medicine related osteonecrosis of the jaws (MRONJ). And she is the surgeon of Oral & Maxillofacial region. In this area, she researched about orthognathic surgery.
First, for academic evaluation, she was interested in medication-related osteonecrosis of the Jaw, and she has researched MRONJ at molecular and clinical levels. Second, for clinical evaluation, she has researched cone-beam computed tomographic study of orthognathic surgery.
1. MRONJ research:
Bisphosphonates have been known to suppress osteoclast activity, survival, and recruitment. In this study, we tested effects of BPs on expression of two critical genes for osteoclastogenesis, M-CSF, and OPG in the process of osteoblast differentiation from hMSC. The findings of this study show new light on the present BPONJ occurrence theory based on the osteoclastic activity of BPs. Also, a more advanced and developed theory for BRONJ occurrence may be obtained by combining the osteoclast inhibition mechanism and the effects on osteoblastic differentiation by BPs.
2, Orthognathic surgery research:
These studies aimed to compare the effectiveness of posterior bending osteotomy and grinding techniques for orthognathic surgery in patients with facial asymmetry using cone-beam computed tomography (CBCT). Posterior bending osteotomy is recommended over the grinding method for patients with severe facial asymmetry, in order to ensure a symmetric and esthetic facial profile by allowing passive adaptation between the mandibular segments.