Excerpt from Clinical Transplants 2012
Five -year Outcomes after a Change from a Cyclosporin -based to a 'Low -dose' Tacrolimus- based Primary Immunosuppression Regimen for Incident Kidney Transplants - The Glasgow Experience
Colin C. Geddes, Alan G. Jardine, David Kingsmore, Enric Murio, Laura Buist, Vlad Shumeyko, Neal Padmanabhan, Conal Daly, Elton McGregor, Margaret McMillan, Siobhan McManus, R. Stuart C. Rodger, and Marc Clancy Glasgow Renal and Transplant Unit, Western Infirmary, Glasgow, United Kingdom Corresponding
The Glasgow Transplant unit is one of two kidney transplant units in Scotland. It has provided adult and paediatric kidney transplant services to the West of Scotland (a population of approximately 2.8 million) since the first transplant in 1968. Since then, more than 3000 kidney transplants have been performed. In the last three decades, minimisation of calcineurin inhibitor exposure has been an interest in our unit (1 -5). Calcineurin inhibitors (CNI) are effective at preventing immunological rejection of solid organ transplants, but in the standard doses used clinically, are associated with renal haemodynamic (6) and histological changes (7), which may represent nephrotoxicity.