TFLBUILDING

High Mean Fluorescence Intensity Donor-Specific Anti-HLA Antibodies Associated With Chronic Rejection Postliver Transplant

O'Leary JG, Kaneku H, Susskind BM, Jennings LW, Davis GL, Klintmalm GB, Terasaki PI

http://www.ncbi.nlm.nih.gov/pubmed/21672151

Developing donor specific HLA antibodies (DSA) after liver transplant is not without risk. In a retrospective, case-control study by O'Leary et al showed that liver transplant recipients with chronic rejection were more likely to have de novo DSA (62%) compared to the functioning patients (with only 38% DSA positivity (p=0.047)). This finding indicates that DSA may be a major cause of allograft loss in liver transplant, just as it has been shown to be in other transplanted solid organs.