High Mean Fluorescence Intensity Donor-Specific Anti-HLA Antibodies Associated With Chronic Rejection Postliver Transplant

O'Leary JG, Kaneku H, Susskind BM, Jennings LW, Davis GL, Klintmalm GB, Terasaki PI

Developing donor specific HLA antibodies (DSA) after liver transplant is not without risk. In a retrospective, case-control study by O'Leary et al showed that liver transplant recipients with chronic rejection were more likely to have de novo DSA (62%) compared to the functioning patients (with only 38% DSA positivity (p=0.047)). This finding indicates that DSA may be a major cause of allograft loss in liver transplant, just as it has been shown to be in other transplanted solid organs.