Pretransplant Donor-Specific Antibodies in Cytotoxic Negative Crossmatch Kidney Transplants: Are They Relevant?


Gupta A, Iverson V, Varagunam M, Bodger S, Sinnott P, Thuraisingham RC


The presence of preformed DSA had no impact on delayed graft function, incidence of AMR or one-year graft survival, but a tendency toward lower 5-year graft survival was seen. A multivariate analysis demonstrated a six-fold increased risk of graft failure in DSA positive patients.