Clinical Relevance of Pretransplant Donor-Specific HLA Antibodies Detected by Single-Antigen Flow-Beads


Amico P, Hönger G, Mayr M, Steiger J, Hopfer H, Schaub S


The cumulative incidence of AMR (clinical and subclinical) at day 200 post-transplant in patients with preformed DSA was 55%, significantly higher compared to 6% in patients without preformed DSA. Five-year graft survival was significantly worse in patients with preformed DSA who also had AMR, compared to patients without preformed DSA and patients with preformed DSA without AMR (68% vs. 89% vs. 87%, p=0.002).